A cell line-derived xenograft or CDX model is a gold-standard model used for the research and testing of anti-cancer therapies. Human tumor samples are cultured as cell lines and implanted into mouse models to test the efficacy of anti-tumor compounds in vivo.
Our broad range of tumor lines gives you a wide variety of testing alternatives for your agent. We evaluate our xenograft model portfolio on a regular basis for response to standards of care to aid the design of combination studies.
At ProOnco Therapeutics, we offer a range of a wide range of histotypes, including broad models like non-small cell lung cancer, breast cancer or colon cancer, as well as tumor models with a high medical need like ovarian cancer, leukemia, lymphoma, or prostate cancer.
What typically you will have from our model collection:
In addition to efficacy evaluation in CDX models, we can also provide service with:
At ProOnco Therapeutics, we offer a range of a wide range of histotypes, including broad models like non-small cell lung cancer, breast cancer or colon cancer, as well as tumor models with a high medical need like ovarian cancer, leukemia, lymphoma, or prostate cancer. Following please find our large collection of xenograft models:
|
Tumor Types |
Cell lines |
|
Bladder (6) |
HT-1376, HTB-9, J82,RT112/84, T24/83,UM-UC-3 |
|
Breast (22) |
MDA-MB-468, Bcap-37,Cal51,HCC1428,HCC1500, HCC1806, HCC1937, HCC1954, HCC-70,JIMT-1,MCF-7, MDA-MB-231,MDA-MB-361,MDA-MB-436, MDA-MB-453, MFM-223,MX-1, SUM 159PT,SUM-52PE,T-47D,ZR-75-1 |
|
Brain (5) |
D283 Med (MBM), D341 Med (MBM), LN-229, U251,U87 MG(GBM), |
|
Cervical (4) |
HeLa, MES-SA, MES-SA/Dx5, SW756 |
|
Colon (27) |
CoLo 205, Cac0-2, Colo 320 DM, Colo201, DLD-1, GP2d, GP5d, HT-29, HCT15, HCT-116, HT55, KM12, LoVo, LS180, LS174T, LS411N,LS513, RKO, SNU-C2B, SW403, SW48, SW480, SW620, SW837, SW948, T84, WiDr |
|
Esophageal (4) |
KYSE-520, KYSE-70, OE21, T.T |
|
Gastric (13) |
AGS, BGC-823,HGC-27, HS 746T, MGC-803,MKN45, NCI-N87, NUGC-4, SNU-1, SNU-16, SNU-5, SNU-601, TGBC11TKB |
|
Leukemia (14) |
CCRF-CEM, HEL 92.1.7, HL-60, Jurkat, K562, Kasumi-1, KG-1, M-NFS-60, MOLT-4, MV-4-11, NALM-6, SET-2, SUP-B15, THP-1 |
|
Lymphoma (21) |
Daudi, DoHH2,Farage, Granta-519, HDLM-2, Maver-1,Mino,NAMALWA, OCI-LY10, Pfeiffer, Raji, Ramos, REC-1, RL, SU-DHL-2,SU-DHL-6, SU-DHL-10, Toledo, U937, WSU-DLCL2, Z-138 |
|
Liver (15) |
BEL-7404, Hep3B, HepG2, Huh 7, JHH-4, JHH-7, MHCC97H, PLC/PRF/5, QGY-7703, SK-HEP-1, SMMC-7721, SNU-182, SNU-398, SNU-761, SNU-878 |
|
Lung (NSCLC, 35) |
A-427, A549, Calu-1,Calu-3, Calu-6, DV-90, EBC-1, HCC-1588, HCC-2279, HCC-40046, HCC-827, LK-2, MSTO-211H, NCI-H1299, NCI-H1650, NCI-H1703, NCI-H1836, NCI-H1975, NCI-H1993, NCI-H2110, NCI-H2122, NCI-H2228, NCI-H226, NCI-H2291, NCI-H292, NCI-H322, NCI-H358, NCI-H441, NCI-H460, NCI-H520, NCI-H647, NCI-H727, PC-9, SK-LU-1, SK-MES-1, |
|
Lung (SCL, 8) |
NCI-H125, NCI-H1417, NCI-H1437, NCI-H446, NCI-H526, NCI-H69, NCI-H82,SHP-77, DMS53 |
|
Melanoma (6) |
A375, COLO 829, MDA-MB-435S, SK-MEL-24, SK-MEL-28, SK-MEL-5 |
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Myeloma (7) |
KMS-11, KMS-28BM, MM.1S, MOLP-8, NCI-H929, OPM2 RPMI-8226, |
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Ovary (6) |
A2780, ES-2,KURAMOCHI, OV90, OVCAR-3, SK-OV-3 |
|
Pharynx (1) |
FaDu |
|
Placenta (1) |
Jeg-3 |
|
Pancreas (13) |
AsPC-1, BxPC-3, HPAC, KLM-1,KP-4, Mia PaCa-2, PANC-1, Panc 02.13, Panc 04.03, Panc 10.05, PK-1, PK-59, SW1990 |
|
Prostate (6) |
22Rv1, DU145, LNCaP, LNCaP-FGC, PC-3, VCap |
|
Renal (6) |
786-O, A498, ACHN, Caki-1, SK-NEP-1,UM-UC-14 |
|
Skin (1) |
A431 |
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Sarcoma (6) |
143B, A673, HT1080, KHOS/NP, SJSA-1, U2OS |
|
Thyroid (2) |
MZ-CRC-1, TT (ATCC, CRL-1803) |
|
Urinary (2) |
BFTC-905, RT112/84 |
|
Neuroblastoma(1) |
CHP-134 |
ProOnco can be contacted at info@pro-onco.com for any further questions or information required on our xenograft models, or for information on other ProOnco products and services.
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